Nicotinamide Mononucleotide (NMN) is a direct precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a vital coenzyme involved in numerous cellular processes, including energy metabolism and DNA repair. As part of the natural aging process, cellular NAD+ levels decrease over time.  Research has shown that NMN supplementation can significantly increase NAD+ levels in various tissues, including the brain, thereby enhancing cognitive function and promoting overall cellular health (Ramanathan et al., 2022; Tarantini et al., 2019; Yi et al., 2022). Furthermore, NMN has been linked to improved mitochondrial function, which is essential for energy production and reducing oxidative stress, a key factor in aging (Nadtochiy et al., 2018; Miao et al., 2020).

Studies indicate that NMN supplementation not only supports metabolic health but also has cardioprotective effects, potentially mitigating age-related decline in heart function (Nadtochiy et al., 2018; Hong et al., 2020). By restoring NAD+ levels, NMN activates sirtuins, a family of proteins that play a crucial role in cellular health and longevity (Yano et al., 2015; Poddar et al., 2019). This activation enhances mitochondrial DNA repair and promotes healthy cellular aging, making NMN a cornerstone of our formulation.

Urolithin-A, another critical component of Live Longer - NMN+, has garnered attention for its ability to induce mitophagy—the process by which damaged mitochondria are removed and replaced with healthy ones. This process is vital for maintaining cellular energy levels and function (Christian & Shadel, 2014; Lee et al., 2023). Research has demonstrated that Urolithin-A supplementation can improve muscle function and overall mitochondrial health, particularly in aging populations (Luan et al., 2021; D’Amico et al., 2021). By incorporating Urolithin-A into our formula, we aim to enhance the benefits of NMN, ensuring that your cells are not only energized but also functioning optimally.

Trimethylglycine (TMG) Supports methylation processes that are essential for maintaining DNA integrity and regulating gene expression. TMG also helps to counterbalance the methylation demands associated with NAD+ synthesis from NMN, ensuring optimal cellular function. TMG is known for its role in promoting healthy homocysteine levels, which is crucial for cardiovascular health (Singh et al., 2021).

Plays a key role in energy metabolism and cellular longevity by supporting mitochondrial function and reducing systemic inflammation. Ca-AKG synergizes with NMN by enhancing energy pathways and providing additional support for metabolic health. Ca-AKG has been shown to support mitochondrial function and may play a role in extending lifespan by improving metabolic health (Sharma et al., 2023; Bai et al., 2022).